Navigation Links
A*STAR scientists create stem cells from a drop of blood
Date:3/20/2014

1. Scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPSCs) from a single drop of finger-pricked blood. The method also enables donors to collect their own blood samples, which they can then send to a laboratory for further processing. The easy access to blood samples using the new technique could potentially boost the recruitment of greater numbers and diversities of donors, and could lead to the establishment of large-scale hiPSC banks.

2. By genetic reprogramming, matured human cells, usually blood cells, can be transformed into hiPSCs. As hiPSCs exhibit properties remarkably similar to human embryonic stem cells, they are invaluable resources for basic research, drug discovery and cell therapy. In countries like Japan, USA and UK , a number of hiPSC bank initiatives have sprung up to make hiPSCs available for stem cell research and medical studies.

3. Current sample collection for reprogramming into hiPSCs include invasive measures such as collecting cells from the bone marrow or skin, which may put off many potential donors. Although hiPSCs may also be generated from blood cells, large quantities of blood are usually required. In the paper published online on the Stem Cell Translational Medicine journal, scientists at IMCB showed for the first time that single-drop volumes of blood are sufficient for reprogramming into hiPSCs. The finger-prick technique is the world's first to use only a drop of finger-pricked blood to yield hiPSCs with high efficiency. A patent has been filed for the innovation.

4. The accessibility of the new technique is further enhanced with a DIY sample collection approach. Donors may collect their own finger-pricked blood, which they can then store and send it to a laboratory for reprogramming. The blood sample remains stable for 48 hours and can be expanded for 12 days in culture, which therefore ext
'/>"/>

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
656-826-6273
Biomedical Sciences Institutes (BMSI)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. A*STAR scientists discover potential drug for deadly brain cancer
3. A*STAR scientists solve century-old mystery by finding stable haploid strains of Candida albicans
4. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
5. A*STAR scientists discover novel hormone essential for heart development
6. A*STAR signs agreement with Nestlé to strengthen food & nutrition R&D in Singapore
7. A*STAR scientists discover proteins role in human memory and learning functions
8. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
9. Queens scientists seek vaccine for Pseudomonas infection
10. Scientists produce eye structures from human blood-derived stem cells
11. American Society of Plant Biologists honors early career women scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:5/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, reminds investors and media that  Mr. David Tunnell ... SECURE CONNEXIONS AMERICA 2015, held in Washington DC ... conference is organized into a series of nine session tracks. ... Fraud: Where is the Trust in Cyberspace? and will ...
(Date:4/27/2015)... , Apr. 27, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... to pre-order customers the first week of May, 2015 ... month of May. Gino Pereira ... milestone for the company as Wocket® enters the consumer ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... do some end up with chronic pain while others recover ... to track participants with a new back injury has found ... literally. A new Northwestern Medicine study shows for ... sections of the brain --- related to emotional and motivational ...
... the first time, how a potted plant,s roots are arranged in ... presented at the Society for Experimental Biology meeting on 30th June, ... plants grow over 40% larger. From their 3-D MRI ... roots to the pot,s walls. It is likely that the plants ...
... signature sequences is a defense mechanism. For scientists working in ... tool. With a newly discovered component of an adaptive bacterial ... DNA that they say can be easily customized for a ... apart DNA strands in defined locations are essential for editing ...
Cached Biology News:Why chronic pain is all in your head 2Programmable RNA complex could speed genome editing in the lab 2Programmable RNA complex could speed genome editing in the lab 3
(Date:5/27/2015)... , May 26, 2015 Research and ... the "Global Breast Cancer Monoclonal Antibodies Market ... Globally, Roche seems to dominate the breast ... Its block buster molecule, Herceptin has been able ... was found that breast cancer cells become recalcitrant ...
(Date:5/27/2015)... 27, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... 2015. Aviv Boim , CEO ... work to generate functional specific antibodies, targeting identified cancer ... are encouraged by the development progress. We are excited ... which modulate immune checkpoints gain clinical acceptance for cancer ...
(Date:5/27/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO ) ... therapies for cancer, announced today that Dr. Marnix ... will be making an Industry Expert Theater Presentation at ... on Saturday, May 30, 2015, from 3 ... in McCormick Place. Dr. Bosch will provide ...
(Date:5/27/2015)... 2015  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... status of the Company,s Series A and Series ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO At March ... of Series A Preferred Stock and Series A-1 ...
Breaking Biology Technology:Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 2Global Breast Cancer Monoclonal Antibodies Market Outlook 2020 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3
... SYDNEY, Australia, Dec. 14 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS; ... SA to,market and distribute its asthma diagnostic tool, ... the 13 European countries included in the,successful mutual ... Officer Dr Alan Robertson., "Bronchial challenge testing ...
... is,probably the last back pain treatment you will ... pills, struggling through exercise,programs...and...unnecessary and risky injections and ... - they are a thing of the,past., ... on relieving,severe back and leg pain. Dr. Flock ...
... Systems, a leader in the field of,sleep diagnostic ... an,exclusive agreement with the Beth Israel Deaconess Medical ... Coupling (CPC) technology,developed by Drs. Robert Thomas, Ary ... technology represents a breakthrough in how sleep can ...
Cached Biology Technology:Pharmaxis Appoints Portuguese Distributor for Aridol 2Amazing Treatment Relieves Serious Back Pain Without Dangerous Drugs, Injections or Surgery! 2Embla Systems in Collaboration with Beth Israel Deaconess Medical Center to Develop Cardio-Pulmonary Coupling Technology 2
... Proteins ,Contains sufficient components to prepare ... gel analysis , ,Includes:, , Mem-PER ... , (contains sufficient reagents for extracting 25 ... of 10 mg each) Kit , ...
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
... is a hairpin primer labeled with ... and non-fluorescent quencher) and a 3 ... is identical to the UniPrimer provided ... (S7901) and is provided at a ...
Rabbit polyclonal to MCP2 ( Abpromise for all tested applications). entrezGeneID: 6355 SwissProtID: P49873...
Biology Products: