Navigation Links
25 years of DNA on the computer
Date:1/3/2014

DNA carries out its activities "diluted" in the cell nucleus. In this state it synthesises proteins and, even though it looks like a messy tangle of thread, in actual fact its structure is governed by precise rules that are important for it to carry out its functions. Biologists have studied DNA by observing it experimentally with a variety of techniques, which have only recently been supplemented by research in silico, that is to say, the study of DNA by means of computer simulations. This is a recent area of study, but it has already given a major contribution to knowledge in this field. Angelo Rosa, a theoretical physicist of the International School for Advanced Studies (SISSA) in Trieste, with the collaboration of Christophe Zimmer, an experimental physicist from the Pasteur Institute in Paris has assessed the state of the art of this novel but powerful approach in a systematic review that has just been published in the journal International Review of Cell and Molecular Biology.

"Apart from some rare exceptions, we reviewed virtually all of the models developed to date", explains Rosa. "The review is mainly aimed at biologists in that we have made minimal use of mathematical formulas which hamper reading. I think this is the first review of its kind. The paper is actually also interesting for physicists and mathematicians who are approaching this new field for the first time".

The two physicists reviewed 25 years of computational models: "in this relatively short time span the models have become increasingly sophisticated and this, thanks to the development of computers", explains Rosa. "Today we are able to make far more detailed and predictive simulations, which allow us to lead the work of experimental researchers in previously unthought-of directions".

"This is a useful tool which, without going into mathematical detail, provides the biologist with an overview of the type of studies that will increasingly complement the more traditional approaches" continues Rosa. "Today, for example, we already have software programmes which, starting from experimental data, allow us to reconstruct the structure of specific portions of chromosomes. I think that if computers continue to evolve as they have done until now and there's no reason to doubt this we'll be able to reconstruct entire chromosomes".

"At the present time, the future prospects of in silico research into nuclear DNA are twofold", concludes Rosa, "to understand in detail the dynamics of gene expression (the details of protein synthesis) and to identify precisely where the chromosomes are when DNA unravels in the nucleus".


'/>"/>

Contact: Federica Sgorbissa
comunicazione@medialab.sissa.it
39-040-378-7644
International School of Advanced Studies (SISSA)
Source:Eurekalert  

Related biology news :

1. Oceans acidifying faster today than in past 300 million years
2. Ice sheet collapse and sea-level rise at the Boelling warming 14,600 years ago
3. 50 years of bird poop links DDT with changing bird menus
4. UH makes Princeton Reviews Green List 3 years in a row
5. Global warming has driven Europes mountain plants to migrate 2.7 meters upwards in 7 years
6. Jurassic pain: Giant flea-like insects plagued dinosaurs 165 million years ago
7. Scientists read the ash from the Icelandic volcano 2 years after its eruption
8. Special issue of the EMBO Journal celebrates 30 years of Wnt research
9. 10 million years to recover from mass extinction
10. Development of prosthetic hands stagnated for 20 years
11. Over 30 years of global soil moisture observations for climate applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
25 years of DNA on the computer
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:5/24/2016)... Calif. , May 24, 2016 Ampronix facilitates superior patient care by ... LMD3251MT  3D medical LCD display is the latest premium product recently added to the ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... Raleigh, NC (PRWEB) , ... June 27, 2016 ... ... a mission to bring innovative medical technologies, services and solutions to the healthcare ... development and implementation of various distribution, manufacturing, sales and marketing strategies that are ...
(Date:6/27/2016)...   Ginkgo Bioworks , a leading organism ... today awarded as one of the World Economic ... most innovative companies. Ginkgo Bioworks is engineering biology ... world in the nutrition, health and consumer goods ... customers including Fortune 500 companies to design microbes ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
Breaking Biology Technology: