Navigation Links
23andMe and ALSPAC identify 16 new genetic associations for pollen, dust-mite and cat allergies
Date:7/2/2013

Mountain View, Calif. The largest genome-wide association study ever conducted on common allergies, including pollen, dust-mite and cat allergies, has identified 16 new genetic associations related to the condition. The study, conducted in collaboration between 23andMe, the leading personal genetics company, and the Avon Longitudinal Study of Parents and Children (ALSPAC), examined data for more than 53,000 individuals. The study also identified eight genetic variations for allergies that have previously been associated with asthma. Genes implicated in the study highlight a series of key pathways in the biological basis of common allergies.

Allergies and allergic asthma are among the most common diseases in the industrialized world. In the United States, a 2005 survey showed that more than half of the population tested positive for sensitization to at least one of 10 common allergens, a considerable increase over results of the same survey performed approximately 10 years earlier.[i]

"We've seen some substantial increases in prevalence of allergies and asthma," said David Hinds, Ph.D., author and 23andMe principal scientist. "Although environmental factors certainly play a role, our study reinforces the genetic link between common allergens and a person's susceptibility to experiencing an allergic reaction. Additionally, current estimates of the heritability of allergies are high, which suggests that understanding the genetic factors underlying allergic conditions may be key to understanding who might be most likely to suffer from allergies and how the condition might best be treated."

The study, titled "A Genome-Wide Association Meta-Analysis of Self-Reported Allergy Identifies Shared and Allergy-Specific Susceptibility Loci" was published online on June 30, 2013 in Nature Genetics, a leading monthly, international scientific journal.

23andMe selected three common self-reported allergy phenotypes pollen, dust-mite and cat allergies for which comparable data was available both in the 23andMe research community and in a cohort from the Avon Longitudinal Study of Parents and Children (ALSPAC). Data from both organizations was then included in a genome-wide association meta-analysis.

"Allergy is an important component of many diseases, including asthma, eczema and hay fever, which together account for a huge burden on patients and the health services." said professor John Henderson of ALSPAC. "This is a very exciting time for allergy research. Genetic discoveries have identified specific pathways of allergy development that are not shared with allergic diseases like asthma. Understanding these pathways could lead to eventual development of drugs that cure or prevent allergy rather than just suppressing its symptoms."

"One of the key features of this work is the demonstration that with a suitably sized study, the analysis of medically relevant questionnaire data alongside genetic variation has the potential to yield important information concerning the underlying biology of a complex outcome," said Dr. Nic Timpson of ALSPAC. "Indeed, through this collaborative interaction with colleagues from EAGLE where specific tests of allergic sensitization were available, we were able to independently replicate many of the findings made here."

Also published on June 30, 2013 in Nature Genetics was a companion study called, "Meta-Analysis of Genome-Wide Association Studies Identifies 10 Loci Influencing Allergic Sensitization". This study had similar methodology to the 23andMe/ALSPAC study but was conducted by the Early Genetics and Lifecourse Epidemiology research cohort (EAGLE) using clinically defined data instead of self-reported data. This provided the opportunity to compare results of self-reported data to study results based on clinically defined data. The results from the studies were generally very consistent, highlighting many of the same genes and pathways.

"This coordinated approach to research significantly accelerates the replication and validation processes associated with solidifying new genetic discoveries," said David Hinds, Ph.D, 23andMe principal scientist.

"Through this collaborative effort, we have identified several genes that are responsible for a considerable proportion of allergy in the population," said Klaus Bnnelykke, MD, PhD and principal scientist from EAGLE. "This is an important step in allergy research."


'/>"/>

Contact: Kendra Brogden
kbrogden@wcgworld.com
415-658-9765
23andMe Inc.
Source:Eurekalert

Related biology news :

1. 23andMe identifies multiple genetic factors impacting development of nearsightedness
2. 23andMes Ancestry Composition reveals peoples ancestral origins going back 500+ years
3. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
4. 23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions
5. 23andMe opens its API to developers
6. 23andMe contributes to genetic discoveries related to male pattern baldness
7. 23andMe identifies 5 significant genetic associations for hypothyroidism
8. Scientists identify promising antiviral compounds
9. NIH to fund collaborations with industry to identify new uses for existing compounds
10. Study helps managers identify regions with multiple threat potential, including wildfires
11. Iris Biometrics Leader EyeLock Joins the FIDO Alliance to Help Identify More Secure Replacement for Usernames and Passwords
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia ... be hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” ... pathology adoption best practices and how Proscia improves lab economics and realizes an ...
(Date:10/11/2017)... Georgia (PRWEB) , ... October 11, 2017 , ... Disappearing ... taking the lives of over 5.5 million people each year. Especially those living in ... greenovative startup Treepex - based in one of the most pollution-affected countries globally - ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
Breaking Biology Technology: