Navigation Links
2 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants
Date:9/24/2009

in is a single cell," Dubnau explains, "but they're more complex, structurally, than most cells. You can think of the cell body in neurons as the base of a vast tree-like structure, a tree with literally thousands of branches. These projections -- axons and dendrites -- carry information, respectively, out of and into each neuron from other neurons.

"If neurons are to function properly, they need to control with exquisite precision where each protein in their structure is synthesized. When that process is disrupted in the human brain, severe cognitive problems can ensue. Fragile-X mental retardation is an example. Remarkably, we geneticists know a lot about how gene expression is regulated in the nucleus, where DNA is transcribed to RNA. But we know surprisingly little about the spatial regulation of protein synthesis. From the perspective of the cell-body, you have to specify on which 'leaf' of the neuronal tree a protein is being made."

Dubnau notes that the project is significant from the standpoint of basic science; the regulatory mechanism he describes is still unknown. It also promises to shed new light on brain illnesses -- Fragile-X is only one of several -- "in which it has become clear that spatial and temporal control" of the process by which RNAs are translated into brain proteins in some manner goes awry.

"We'll focus at first on Fragile-X as a kind of test case for our approach," Dubnau says. "At the same time, we hope to provide the neuroscience community a library of fruit fly strains that will enable researchers around the world to query the regulation of genes in the nervous system, one by one. If many researchers take this approach, we can envision a collaborative process, akin to what computer scientists call parallel processing, that might open new windows on regulatory anomalies implicated in mental illness."


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Caltech neuroscientists find brain region responsible for our sense of personal space
2. Neuroscientists discover long-term potentiation in the olfactory bulb
3. Bipolar disorder genes, pathways identified by Indiana University neuroscientists
4. Advertisers, neuroscientists trace source of emotions in brain
5. Early spring time for Edinburgh? Study predicts effect of global warming on spring flowers
6. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
7. Spring cold snap helps with stream ecosystem research
8. Springer to collaborate with the Human Genome Organization
9. Springer launches SpringerImages
10. Battle of the sexes benefits offspring, says research
11. Bisphenol A exposure in pregnant mice permanently changes DNA of offspring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. (OTCQB: ... mobile commerce market, announced today that its shares of ... to be issued in its proposed underwritten public offering ... listing on The Nasdaq Capital Market, subject to closing ... stock and warrants, and will trade under the symbol ...
(Date:8/21/2014)... might seem easy to ignore, but they are the ... depend upon. Humans are increasingly dependent on algae, too, ... and sink it to the bottom of the ocean. ... laboratory experiments, researchers have evidence showing that viruses infecting ... algae,s blooms, even when all else stays essentially the ...
(Date:8/21/2014)... 2014 /PRNewswire-iReach/ -- LiveScan Service Provider  Binary ... a partnership with Gabriel Health Institute, one of ... Certified Nursing Assistant preparatory schools. The agreement ... member of Binary,s LiveScan service provider,s owner/operator team; ... its service capabilities by widening the service ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3Viruses take down massive algal blooms, with big implications for climate 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3
... comet-like tail Mercurys gravity is too weak ... evaporated from the surface by solar photons or other ... escape velocity by solar radiation pressure. The neutral components ... points away from the Sun. Baumgardner et al. study ...
... of a massive online Encyclopedia of Life (EOL) were ... Entertainment and Design (TED) Conference in Monterey, California. ... and a fascinating resource for anyone interested in the ... unique collaboration between scientists and the general public. ...
... the significance of taste to both human gratification and survival, ... Taste provides both pleasure and protection. Often taken ... into their mouths. Taste mediates recognition of a substance and ... taken into the body, or rejected as inappropriate. ...
Cached Biology News:AGU journal highlights -- Feb. 26, 2008 2AGU journal highlights -- Feb. 26, 2008 3AGU journal highlights -- Feb. 26, 2008 4AGU journal highlights -- Feb. 26, 2008 5AGU journal highlights -- Feb. 26, 2008 6MBL develops infrastructure and portal for Encyclopedia of Life 2MBL develops infrastructure and portal for Encyclopedia of Life 3MBL develops infrastructure and portal for Encyclopedia of Life 4MBL develops infrastructure and portal for Encyclopedia of Life 5From delicious to death: Understanding taste 2
(Date:8/20/2014)... 20, 2014 Not long ago, it ... should be performed late in the development cycle – ... current regulatory trends suggest that, like many things GxP, ... In recent years, multiple drug sponsors have been required ... specific questions during phase I/II. It’s not only clinical ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Shimadzu Scientific Instruments has introduced ... Nexera-i, adding to the company’s extensive line-up of ... intuitive operating environment, and full automation, the i-Series ... for conventional to ultra-high-speed analysis. , ... design so users can begin building the lab ...
(Date:8/19/2014)... Calif. (PRWEB) August 19, 2014 ... campaign to raise $200,000 to fund a corporate ... device. , This development is a critical ... model of care to the implementation of personalized ... method of practicing medicine. , Indiegogo contributions will ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2EQ-5D™ Assessment Now Available for iPad 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3
... BIRMINGHAM, Ala., Oct. 31 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... quarter ended September 30, 2008., Third Quarter ... ended September 30, 2008, the Company reported,collaborative and ... to $20.5 million for the three months ended ...
... and waves erode billions of tons of soil from ... plagued with excessive amounts of suspended sediment. According to ... the largest nonpoint source pollution in the environment. , ... obvious wind, water and wave forces breaking apart particles ...
... 30 AVAX Technologies, Inc.,(OTC Bulletin Board: AVXT) ... it closed a bridge loan financing pursuant to ... by the Amendment to Convertible,Note and Warrant Purchase ... Company sold convertible promissory notes,(the "Notes") in the ...
Cached Biology Technology:BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 2BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 3BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 4BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 5BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 6BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 7BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 8BioCryst Reports Third Quarter 2008 Financial Results and Provides Corporate Update 9Virginia Tech engineers identify conditions that initiate erosion 2Virginia Tech engineers identify conditions that initiate erosion 3AVAX Technologies, Inc. Announces Closing of Bridge Loan Financing 2
... Mouse L1210 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
ID clarifier: Without ethidium bromide...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
...
Biology Products: