Navigation Links
2 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants
Date:9/24/2009

brain-wide circuit diagram for the mouse, and using this as reference, attempt to determine alterations in the corresponding circuits of mouse models of neuropsychiatric disorders.

A key question about making any map concerns its scale, which determines its level of detail. At the finest scale of individual synapses and processes of every neuron, the brain shows a great deal of variability from individual to individual. At the macroscopic level, gross brain compartments such as the cerebellum or lobes of the cerebral cortex are too large to be nodes on a brainwide circuit map because they contain many sub-compartments. However, there exists a nontrivial "mesoscopic" scale, intermediate between these two levels that has been studied classically by neuroanatomists and is suitable for a meaningful circuit map.

"At the mesoscopic scale, neuroanatomists have found that there are well-defined regions -- hundreds of them -- and the circuitry we will be mapping is that between these regions," says Mitra. "This mesoscopic circuit is probably encoded within the species genome and is grown during brain development. Parts of this mesoscopic circuitry may be altered from its normal state in neuropsychiatric disorders."

While the current lack of a circuit diagram at the whole-brain level is "arguably the biggest knowledge gap in contemporary neuroscience," according to Mitra, this first phase of the project is but the prelude to another no less fundamental in importance. "The second phase will be to compare a number of model mice bearing genetic mutations, to see how connectivity in their brains compares with that of the 'reference' map," explained Mitra. "There is a parallel here with the Human Genome Project. The determination of a reference genome enabled genome-wide scans of mutations corresponding to disease phenotypes. In this case, we want to see how the brain-wide connectivity map is altered in the mice with mutations associated with neurol
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Caltech neuroscientists find brain region responsible for our sense of personal space
2. Neuroscientists discover long-term potentiation in the olfactory bulb
3. Bipolar disorder genes, pathways identified by Indiana University neuroscientists
4. Advertisers, neuroscientists trace source of emotions in brain
5. Early spring time for Edinburgh? Study predicts effect of global warming on spring flowers
6. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
7. Spring cold snap helps with stream ecosystem research
8. Springer to collaborate with the Human Genome Organization
9. Springer launches SpringerImages
10. Battle of the sexes benefits offspring, says research
11. Bisphenol A exposure in pregnant mice permanently changes DNA of offspring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 2014 Research and Markets  has announced ... (BI) Market 2014-2018" report to their offering. ... The term BI refers to applications and technologies that ... information about a company,s operations. BI help organizations to ... for example, metrics on sales, production, and internal operations. ...
(Date:7/29/2014)... been plaguing the Northern Territories in Canada and have ... the U.S. continue on. NASA,s Aqua satellite collected ... MODIS, instrument on July 26, 2014. Actively burning areas, ... Copious amount of smoke are drifting northward in this ... of Yellowknife. Fire has caused power outages in ...
(Date:7/29/2014)... has received from the National Institutes of Health ... project to support the further development of 23andMe,s ... , Specifically, the grant supports four areas ... to improve the company,s ability to identify novel ... to support the collection of a broader set ...
Breaking Biology News(10 mins):Global SaaS-based Business Intelligence (BI) Market 2014-2018 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 223andMe scientists receive approximately $1.4 million in funding from National Institutes of Health 3
... The treatment of central nervous system (CNS) diseases can ... as recombinant proteins and gene medicines are not easily transported ... to "open the door" of the blood brain barrier. However, ... therapeutics to reach diseased tissue without damaging normal brain tissue ...
... , We,ve all heard examples of animal altruism: Dogs caring ... mates to the surface. Now, a study led by the ... The researchers looked at corn, in which each fertilized ... bit of tissue known as endosperm that feeds the embryo ...
... FAIRFAX, Va.The Society of Interventional Radiology and Society for ... prospective study to evaluate the use of inferior vena ... The studyalong with the formation of the IVC Filter ... August 2010 FDA medical alert detailing the possibility that ...
Cached Biology News:Propping open the door to the blood brain barrier 2Can plants be altruistic? You bet, says new CU-Boulder-led study 2Can plants be altruistic? You bet, says new CU-Boulder-led study 3Medical societies to launch large-scale study on vein filter use 2
(Date:7/30/2014)... COLLEGE PARK, Md. , July 30, 2014 ... with biological components to interrogate biology, but such ... control biology. As such, researchers ... cells for in vitro metabolic engineering ... metabolism on a chip. New devices are envisioned ...
(Date:7/30/2014)... Connecticut Center for Advanced Technology, Inc. ... Hartford, Conn., was awarded a Rural Business Enterprise Grant ... that will determine the feasibility of implementing an ... Rural Development provided $53,000 for CCAT under the Rural ... of the feasibility study in fiscal year 2014. , ...
(Date:7/29/2014)... SoundConnect , an award winning ... to announce the strategic additions of implementation, support, ... Charleston and Atlanta offices. SoundConnect’s organizational expansion ... hosted solutions, collaboration and mobility that improve business ... SoundConnect was founded in 2004, with the mission ...
(Date:7/29/2014)... Human Longevity, Inc. (HLI), a genomics and ... the healthy, high performance human life span, today announced ... expert in machine learning and machine translation as the ... Google where he was Distinguished Research Scientist and the ... HLI Co-Founder and CEO, J. Craig Venter , ...
Breaking Biology Technology:UMD Researchers Bridge Gap between Microelectronics, Biological Systems 2UMD Researchers Bridge Gap between Microelectronics, Biological Systems 3UMD Researchers Bridge Gap between Microelectronics, Biological Systems 4USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3SoundConnect Organization and Culture is Evolving 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3
... ... ... September 3, 2009 -- Researchers at the U.S. Department of Energy,s Argonne National ... technique could lead to better biosensors, disease therapeutics and diagnostic reagents and non-laboratory ...
... , NEW YORK, Sept. 3 Reportlinker.com announces that ... , Proteomics: Technologies and Global Markets ... , , REPORT HIGHLIGHTS , ... increase from $6.7 billion in 2008 to an estimated $7.9 billion in ...
... , EMERYVILLE, Calif., Sept. 3 Adamas Pharmaceuticals, ... data will be delivered as an oral presentation during the ... in San Francisco, CA on September 13, 2009. The presentation ... study of Adamas, triple combination antiviral drug (TCAD) therapy. ...
Cached Biology Technology:Argonne Researchers Develop Method that Aims to Stabilize Antibodies 2Argonne Researchers Develop Method that Aims to Stabilize Antibodies 3Argonne Researchers Develop Method that Aims to Stabilize Antibodies 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 2Reportlinker Adds Proteomics: Technologies and Global Markets Report 3Reportlinker Adds Proteomics: Technologies and Global Markets Report 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 5Reportlinker Adds Proteomics: Technologies and Global Markets Report 6Reportlinker Adds Proteomics: Technologies and Global Markets Report 7Reportlinker Adds Proteomics: Technologies and Global Markets Report 8Reportlinker Adds Proteomics: Technologies and Global Markets Report 9Reportlinker Adds Proteomics: Technologies and Global Markets Report 10Reportlinker Adds Proteomics: Technologies and Global Markets Report 11Reportlinker Adds Proteomics: Technologies and Global Markets Report 12Reportlinker Adds Proteomics: Technologies and Global Markets Report 13Reportlinker Adds Proteomics: Technologies and Global Markets Report 14Reportlinker Adds Proteomics: Technologies and Global Markets Report 15Reportlinker Adds Proteomics: Technologies and Global Markets Report 16Reportlinker Adds Proteomics: Technologies and Global Markets Report 17Reportlinker Adds Proteomics: Technologies and Global Markets Report 18Reportlinker Adds Proteomics: Technologies and Global Markets Report 19Reportlinker Adds Proteomics: Technologies and Global Markets Report 20Reportlinker Adds Proteomics: Technologies and Global Markets Report 21Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2
... signaling of the members of the GPCR ... alternative splicing--which has important implications for drug ... a classical expression profiling and at the ... forms of the gene that are expressed ...
... with 5.6" TFT color screen, without Camera ... digital camera with 8.0 mega pixel resolution. It ... small budget. View image from large 5.6" TFT ... It is suitable to capture image for fluorescent ...
... The binding specificity and signaling of the ... to be modified by alternative splicing--which has ... SpliceArrays you can perform a classical expression ... the different alternatively spliced forms of the ...
Mouse monoclonal antibody raised against a full length recombinant CSNK2A2. NCBI Entrez Gene ID = CSNK2A2...
Biology Products: