Navigation Links
2 neuroscientists from Cold Spring Harbor Laboratory awarded 'transformative' NIH grants
Date:9/24/2009

brain-wide circuit diagram for the mouse, and using this as reference, attempt to determine alterations in the corresponding circuits of mouse models of neuropsychiatric disorders.

A key question about making any map concerns its scale, which determines its level of detail. At the finest scale of individual synapses and processes of every neuron, the brain shows a great deal of variability from individual to individual. At the macroscopic level, gross brain compartments such as the cerebellum or lobes of the cerebral cortex are too large to be nodes on a brainwide circuit map because they contain many sub-compartments. However, there exists a nontrivial "mesoscopic" scale, intermediate between these two levels that has been studied classically by neuroanatomists and is suitable for a meaningful circuit map.

"At the mesoscopic scale, neuroanatomists have found that there are well-defined regions -- hundreds of them -- and the circuitry we will be mapping is that between these regions," says Mitra. "This mesoscopic circuit is probably encoded within the species genome and is grown during brain development. Parts of this mesoscopic circuitry may be altered from its normal state in neuropsychiatric disorders."

While the current lack of a circuit diagram at the whole-brain level is "arguably the biggest knowledge gap in contemporary neuroscience," according to Mitra, this first phase of the project is but the prelude to another no less fundamental in importance. "The second phase will be to compare a number of model mice bearing genetic mutations, to see how connectivity in their brains compares with that of the 'reference' map," explained Mitra. "There is a parallel here with the Human Genome Project. The determination of a reference genome enabled genome-wide scans of mutations corresponding to disease phenotypes. In this case, we want to see how the brain-wide connectivity map is altered in the mice with mutations associated with neurol
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Caltech neuroscientists find brain region responsible for our sense of personal space
2. Neuroscientists discover long-term potentiation in the olfactory bulb
3. Bipolar disorder genes, pathways identified by Indiana University neuroscientists
4. Advertisers, neuroscientists trace source of emotions in brain
5. Early spring time for Edinburgh? Study predicts effect of global warming on spring flowers
6. Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols
7. Spring cold snap helps with stream ecosystem research
8. Springer to collaborate with the Human Genome Organization
9. Springer launches SpringerImages
10. Battle of the sexes benefits offspring, says research
11. Bisphenol A exposure in pregnant mice permanently changes DNA of offspring
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market releases photos ... in Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. ... , CEO of NXT-ID thanked his investors and employees "for their ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... Whether it's rice farming or rice research, very few of ... career in an industry that has been a foundation of ... want their children to be rice farmers, and even fewer ... vital importance to the region. , However, an innovative ...
... sound like Saturday cartoons: a strong-boned rat that can't ... the real hero is citrus juice. , Orange and ... long considered an unavoidable aging disease in which bones ... by Texas A&M University's Vegetable and Fruit Improvement Center ...
... more than 25 million people in sub-Saharan Africa, according ... a vaccine against the virus have achieved limited success. ... infection found widely in that region of Africa ?chancroid ... of HIV as much as 10-fold? , That may ...
Cached Biology News:A rice future for Asia 2Orange, grapefruit juice for breakfast builds bones in rats 2Vaccine shown effective against chancroid 2Vaccine shown effective against chancroid 3
(Date:10/25/2014)... This research report “Biodegradable Plastics Market ... Regenerated Cellulose, PCL), by Application (Packaging, Fibers, Agriculture, ... 2019”, defines and segments the global biodegradable plastics ... global volume and value. , Browse 75 Market ... Slides and in-depth TOC on “Biodegradable Plastics Market ...
(Date:10/25/2014)... A new way to produce engineered skin ... skin grafting technologies, it also speeds up the healing ... in the October issue of STEM CELLS Translational Medicine, ... that result from severe burns and chronic wounds. , ... elements. These wounds heal by contraction, with epithelization (the ...
(Date:10/25/2014)... and NEW YORK , Oct. ... ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical ... it has implemented a 1-for-50 reverse split of ... trading on Friday, October 24, 2014. PlasmaTech,s common ... new CUSIP number 72754H109 and temporary ticker symbol ...
(Date:10/25/2014)... , Oct 24, 2014 Research and ... "Epigenetics Market by Product , Research Area & by ... to their offering. In this report, ... of products, research areas, and end users. The product ... are enzymes, instruments & consumables, kits, and reagents. The ...
Breaking Biology Technology:Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3
... research on an ongoing basis is the most effective ... many companies, the benefits of conducting marketing research and ... be at odds: , ,Marketing research can be ... , ,The traditional solution to this quagmire is to ...
... traveled to an event in Madison, Wis. that was organized ... was designed to bring together three geographic locations of high-technology ... ePrairies third eXtreme Networking event (but the first ... a methodology for dating where men and women come together ...
... market has been steadily advancing. People are starting to feel ... in spite of the gnawing reality that far too many ... will never return. Some US pundits are saying in four ... big trouble, with huge raising deficits and the ever-increasing trade ...
Cached Biology Technology:Talking Bout My Generation: The Evolution of Online Marketing Research 2Talking Bout My Generation: The Evolution of Online Marketing Research 3Mike Rosen Reviews - eXtreme Networking in Madison 2Mike Rosen Reviews - eXtreme Networking in Madison 3The Next Economy - Market Collapses Drive Long-Term Growth 2
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... the Beacon 2000 instrument can be used ... Beacon 2000 Data Manager Software provides the ... directly from the instrument. These data can ... available spreadsheets, such as Microsoft Excel or ...
... This kit allows for quick and reproducible immunoprecipitation ... The system is more reproducible than regular IPs, ... protein A/G agarose without disrupting the agarose bed. ... and Release is reversible, and elution of the ...
... self locking design in ice/water bath ... product number, created to easily match ... availability yet, please order under the ... customer service for assistance. ID clarifier: ...
Biology Products: