Navigation Links
2 genetic wrongs make a biochemical right
Date:10/20/2013

bly has several functions throughout the neuron but its main activity is to repress the translation of as many as 1,000 different mRNAs. By doing this, FMRP controls synaptic plasticity and higher brain function. Mice without the Fragile X gene, for instance, have a 15 to 20 percent overall elevation in neural protein production. It is thought that the inability to repress mRNA translation and the resulting increase in neural proteins may somehow hamper normal synaptic function in patients with Fragile X. But because FMRP binds so many mRNAs, and some proteins become more elevated than others, parsing which mRNA or combination of mRNAs is responsible for Fragile X pathology is a daunting task.

From Frog Egg to Fragile X

For years, Dr. Richter had been studying how translation, the process in which cellular ribosomes create proteins, went from dormant to active in frog eggs. He discovered the key gene controlling this process, the RNA binding protein CPEB. In 1998, Richter found the CPEB protein in the rodent brain where it played an important role in regulating how synapses talk to each other. At this point, his work began to move from exploring the role of CPEB in the developmental biology of the frog to how the CPEB protein impacted learning and memory. A serendipitous research symposium with colleagues at Cold Spring Harbor got him thinking about CPEB and Fragile X syndrome.

"Here I was, an outsider, a molecular biologist who had worked for years with frog eggs, in the same room with neurobiologists and neurologists, when they started talking about Fragile X syndrome and translational activity," said Richter. "It got me thinking that the CPEB protein might be a path to restoring the translational imbalance they were discussing."

Richter knew that CPEB stimulated translation and that FMRP repressed it. He also knew that animal models lacking the CPEB protein had memory deficits and that both proteins bound to many of the
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Babcock Genetics Launches Breed Select Program
2. New genetic discovery could reduce the guesswork in drug dosing
3. What makes us left or right handed? New study rules out strong genetic factors
4. Epigenetic changes observed in blood may point to early stages in Parkinson disease
5. Notre Dame paper sheds light on genetic and physiological basis for metabolic diseases
6. Genetics in Medicine publishes special issue dedicated to genomics in electronic health records
7. JScreen public health initiative launches to fight Jewish genetic diseases
8. Functional genetic variation in humans: Comprehensive map published
9. Better sharing of genetic information in human health
10. African-American study identifies 4 genetic variants associated with blood pressure
11. Early-onset Parkinsons disease linked to genetic deletion
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... from the Copenhagen Centre for Social Evolution and Yale ... that birth weight and -length can partially predict the ... as autism and schizophrenia later in life. The study ... subsequent hospital diagnoses for up to 30 years, and ... study is published today in the Proceedings of ...
(Date:9/17/2014)... Biomedical Research Institute (ICO-IDIBELL), led by David Garcia-Mollev ... accompanying cells in colorectal tumors. Analysis of these ... predict the evolution of the patient and thus ... Biomarkers , Colorectal cancer is ... sexes. About 30,000 new cases are diagnosed each ...
(Date:9/17/2014)... DC A team of researchers working on a Carnegie ... coral growth rates have plummeted 40% since the mid-1970s. ... an important role in this perilous slowdown. , ... facing coral reefs, the team compared current measurements of ... Barrier Reef with similar measurements taken more than 30 ...
Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Five genes to predict colorectal cancer relapses 2Coral growth rate plummets in 30-year comparison 2
... Technology (Caltech) have devised a new techniqueusing a sheet ... of molecules. The technique, which was used to obtain ... at room temperature, can also be used to image ... and other biomolecules. A paper describing the method ...
... prototype model of the first implantable artificial kidney, in ... for dialysis. The device, which would include thousands ... mimic the metabolic and water-balancing roles of a real ... engineers, biologists and physicians nationwide, led by Shuvo Roy, ...
... is a joke no more. In a special September issue ... ( CBE-LSE ), the adage that biology is for science ... "Bio-math" or "math-bio" is in the future for students of ... research articles on new ways to integrate mathematical thinking into ...
Cached Biology News:Caltech chemists develop simple technique to visualize atomic-scale structures 2Caltech chemists develop simple technique to visualize atomic-scale structures 3UCSF unveils model for implantable artificial kidney to replace dialysis 2UCSF unveils model for implantable artificial kidney to replace dialysis 3You say, 'bio-math,' I say, 'math-bio': Crossing science education divide 2
(Date:9/17/2014)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), ... protected regenerative biomaterials and bioimplants processed from human ... clinical study.    The study article, ... Trial Evaluating the Use of Dehydrated ... Therapy vs. Multi-layer Compression Therapy Alone in the ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Immunomic Therapeutics, ... Innovation Research (SBIR) grant to support the continued preclinical ... provide ITI with approximately $255,000 over one year to ... cause of food allergy, affect over one million Americans ... peanut allergy. Tree nut exposure is also a risk ...
(Date:9/17/2014)... , Sept. 17, 2014 Alternative Fuels Americas, ... to form a Special Purpose Vehicle in partnership with Jatro ... centric agro energy company. The SPV shall be called AFAI ... with AFAI as majority shareholder. The SPV shall pursue Jatropha ... , particularly Ethiopia . ...
(Date:9/17/2014)... FOREST, California , 17 de septiembre ... CYRX) ("la compañía"), principal proveedor mundial de ... de las ciencias de la vida, anunció ... compañía de logística global con sede en ... su base de clientes Europa en rápido ...
Breaking Biology Technology:MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 2MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 3MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 4Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... Compendia Bioscience, Inc.,today announced the release and ... high-value product extension of Oncomine,Research Edition for ... includes custom gene filters, integration with Ingenuity,Pathway ... Concepts Map,including the ability to upload custom ...
... Offer Full Range of Fertility Services and ... Dr. John Jain, a,fertility specialist with ... the,country, announced today the grand opening of ... reproductive health center in Santa,Monica, California. The ...
... Features ... Renowned Investment Banker and Biotechnology Company Start-up Leader ... Stelios Papadopoulos, PhD Provides Keynote Address, BOSTON, ... Opportunities Investor Conference, New,England,s largest biotechnology investor forum, will ...
Cached Biology Technology:Compendia Bioscience Announces the Release and Availability of Oncomine(TM) Research Premium Edition 2Pioneer in Reproductive Medicine Opens The Country's First Comprehensive Fertility Practice 22007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 22007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 3
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
ANTI CORTIS BIN GLOB...
ANTI S. ENTERID LPS...
... This DuoSet ELISA Development kit contains ... of sandwich ELISAs to measure natural and ... and serum. Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
Biology Products: