Navigation Links
2 genes influence social behavior, visual-spatial performance in people with Williams syndrome
Date:2/11/2009

ponsible for human behavior," explains Korenberg. This prompted Korenberg's collaboration with Bellugi, who is interested in the cognitive aspects of the disorder, "Genetic contributions to human cognition and behavior are clear but difficult to define," says Bellugi.

Virtually everyone with Williams Syndrome has exactly the same set of genes missing (25 to 28 genes are missing from one of two copies of chromosome 7). There also are rare cases of individuals who retain one or more genes that most people with the disorder have lost.

"I wanted to focus on something that could get me down to just a few genes related to behavior," says senior author Korenberg, also a USTAR professor of pediatric genetics at the University of Utah School of Medicine. "When it became clear that Williams Syndrome is caused by a microdeletion of genes, we could start looking at smaller and smaller gene deletions to study their effect on social behavior."

Two genes in particular, GTF2IRD1 and GTF2I, caught Korenberg's eye. Both encode transcription factors that help regulate the activity of other genes. Although their exact function is unknown, the genes are active in many body tissues and appear to be particularly important in regulating brain and skeletal muscle genes.

In earlier studies, Korenberg and her collaborators linked both GTF2I and GTF2IRD1 to deficits in visual-spatial processing, a hallmark of Williams Syndrome. The researchers are now dissecting the genes' roles even more. "Further parsing the effects of GTF2IRD1 versus GTF2I on spatial construction and social behavior was previously hampered by the small number of cases with fewer than the usual gene deletions and limited cognitive data," explains Korenberg.

To distinguish the roles of the two genes, postdoctoral researcher and study first author Li Dai, Ph.D., combed the genomes of 17 Williams Syndrome patients to identify those who had lost only one GTF2I gene. This allo
'/>"/>

Contact: Phil Sahm
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists uncover new class of non-protein coding genes in mammals with key functions
2. Missing genes link to psoriasis
3. Large DNA stretches, not single genes, shut off as cells mature
4. U-M researchers discover new genes that fuse in cancer
5. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
6. Snails and humans use same genes to tell right from left
7. Boy or girl? Its in the fathers genes
8. New genes present drug targets for managing cholesterol and glucose levels
9. Genes for 9 health indicators
10. Genes determine whether sugar pills work
11. Einstein researchers develop technique to count messages made by single genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... VIEW, Calif. , Nov. 20, 2014 ... higher driver efficiency are piloting the North American and ... number of accidents growing, gesture recognition systems that are ... make a mark in the industry. ... the Automotive Gesture Recognition Market in Europe ...
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... fisheries certifier is failing on its promises as rapidly ... experts from the University of British Columbia (UBC), Scripps ... San Diego and elsewhere. Established in 1997 by ... world,s largest fish retailers, the Marine Stewardship Council (MSC) ...
... to watch the orderly and seemingly choreographed motion of ... However, the formation and the manifold motion patterns of ... of complex systems. A team of physicists from Technische ... versatile biophysical model system that opens the door to ...
... Mo. As the nation becomes more aware of ... are struggling to find ways to make healthy living ... healthy ideas into sustainable changes through the Healthy Lifestyle ... Missouri counties, is aimed at changing environments to increase ...
Cached Biology News:Seafood stewardship questionable: UBC-Scripps experts 2Seafood stewardship questionable: UBC-Scripps experts 3A model system for group behavior of nanomachines 2A model system for group behavior of nanomachines 3Resource-savvy communities generate healthy, sustainable changes 2
(Date:12/19/2014)... Arkansas (PRWEB) December 18, 2014 ... to locate its pilot production facility and future ... develop and produce innovative new materials that safely ... chosen not only because of its historic, strong ... leaders’ efforts to attract leading edge, technology-based companies ...
(Date:12/19/2014)... In contrast to traditional LED lights where ... Valoya uses proprietary LED technology to incorporate their spectra ... which is critical in low proximity installations. The Valoya ... its lifetime which is up to four times longer ... investment cost was clearly higher when compared to traditional ...
(Date:12/19/2014)... 18, 2014   ISN has released its ... Indicators publication series. With data aggregated from ... in 2013 within its online contractor management platform, ISNetworld, ... performance indicator (KPI) statistics. The ... publication is available in two industry specific volumes: ...
(Date:12/17/2014)... Achim Noack has been named global vice president ... position, Noack will assist Jerry Stoller, CEO and president ... and supervise global marketing management and implementation of new ... and experience in the crop protection industry,” says Jerry ... thinking will be a great asset for Stoller Group, ...
Breaking Biology Technology:Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... Introduction , ... is fundamental to environmental protection. In addition to the obvious ... can help trace the source of a dangerous material and ... <P,>A substantial body of research has clearly established ...
... opaque, or solid samples such as blood, ... or phosphors, front-face fluorescence detection offers significant ... Highly concentrated and opaque liquids typically have ... the beam. When measuring fluorescence at 90, ...
... , ... , Fluorescence immunoassay is applied ... stimulation. Interference from other sample components is limited by use ... The detection system includes a T-format sampling module mounting two ...
Cached Biology Technology:Screening and classifying hazardous waste samples 2Screening and classifying hazardous waste samples 3Screening and classifying hazardous waste samples 4Screening and classifying hazardous waste samples 5Immunoassay of Theophylline by fluorescence polarisation 2Immunoassay of Theophylline by fluorescence polarisation 3Immunoassay of Theophylline by fluorescence polarisation 4Immunoassay of Theophylline by fluorescence polarisation 5Immunoassay of Theophylline by fluorescence polarisation 6
... all features of Tracker, plus software to note ... subsection of the arena, and trigger a penaltyThe ... all built around a video camera, frame grabber, ... two fields at once and up to 6 ...
... technology, SilenceMag is the most efficient ... and easy to use, SilenceMag is ... designed for siRNA delivery, SilenceMag allows ... doses of siRNA.,SilenceMag formulation gives reliable ...
Denhardt's Solution is a mixture of blocking agents used in membrane-based hybridization protocols. The solution contains 1% Ficoll (type 400) 1% polyvinylpyrrolidone and 1% bovine serum albumin. Ste...
... liquid handling system from Molecular Devices provides ... one instrument. The system handles a variety ... washing96-, 384- and 1536-welland is the first ... has been optimized to dispense from four ...
Biology Products: