Navigation Links
'1 pill can kill': Effects of unintentional opioid exposure in young children
Date:8/28/2013

Cincinnati, OH, August 29, 2013 -- Medication poisonings among children are an important public health problem. During 2010-2011, an average of 1500 children under 6 years of age was evaluated in emergency departments each year due to unintentional exposure to buprenorphine. Ingestion of strong opioids, such as buprenorphine, can cause central nervous system depression, respiratory depression, and death in young children. In a new study scheduled for publication in The Journal of Pediatrics, researchers study how young children are gaining access to buprenorphine, as well as the effects of unintentional exposure to its different formulations.

Buprenorphine (or the buprenorphine-naloxone combination form), usually sold as a tablet or film strip, is used to treat adults who are addicted to opioids, such as prescription pain medication and heroin. Tablets typically are dispensed in 30-day supply bottles with child-resistant caps, and film strips are dispensed in single-dose, child-resistant foil packs. Dr. Eric Lavonas and colleagues from the Rocky Mountain Poison and Drug Center, the University of Colorado School of Medicine, the University of Oklahoma, Integris Baptist Medical Center, Degge Group, and Venebio Group studied 2380 cases of unintentional exposure to buprenorphine in any form involving children under 6 years of age. The average age of the children was 2 years. Common effects of buprenorphine exposure were lethargy, respiratory depression, miosis (small pupils), and vomiting. Although most children had good outcomes, 587 children were admitted to the intensive care unit and 4 children died.

The researchers found that children were 3.5 to 8.8 times more likely to accidentally ingest the tablets as have unintentional exposure to film strips; 95% of cases involved tablets. In 57% of the cases, at least one root cause for the exposure was identified: 415 cases involved medication stored in sight, in 110 cases the child accessed the medication from a bag or purse, and in 75 cases the medication was not stored in the original packaging. Although most exposures were in the child's own home, 5% of exposures occurred while the child was being watched by another caregiver.

Buprenorphine can be helpful in adult patients who are struggling with addiction issues, but it should not be accessible by children because even a single dose can be life-threatening. Therefore, it is important for all caregivers to be especially vigilant in keeping medications in their original packaging and up, away, and out of sight of children. Although this study focused on just one medication used in a specific population, other more widely used medications, such as those used to treat high blood pressure or diabetes, can be as harmful in young children. According to Dr. Lavonas, "This study underscores the value of providing medications that are particularly dangerous when taken by children, in single dose, child resistant packaging." This approach is likely to be more effective at reducing unintentional exposure than additional efforts at education.


'/>"/>

Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences
Source:Eurekalert

Related biology news :

1. Study adds lung damage to harmful effects of arsenic
2. New tests for determining health and environmental effects of nanomaterials
3. Chemotherapy before radiotherapy for testicular cancer could reduce long-term side-effects
4. Researchers study seleniums effects on horses
5. Study explores effects of review setting on scientific peer review
6. Rapamycin: Limited anti-aging effects
7. Key target responsible for triggering detrimental effects in brain trauma identified
8. Adverse effects of phthalates on ovarian response to IVF
9. Time is of the essence for reducing the long-term effects of iron deficiency
10. Patients use OTC NSAIDs even when they have a high risk of serious side effects
11. Hidden effects of climate change may threaten eelgrass meadows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... NEW YORK , June 23, 2016 ... the trading session at 4,833.32, down 0.22%; the Dow Jones ... the S&P 500 closed at 2,085.45, down 0.17%. Stock-Callers.com has ... INFI ), Nektar Therapeutics (NASDAQ: NKTR ... BIND Therapeutics Inc. (NASDAQ: BIND ). Learn more ...
(Date:6/23/2016)... FRANCISCO , June 22, 2016  Amgen (NASDAQ: ... sponsorship of the QB3@953 life sciences incubator ... human health. The shared laboratory space at QB3@953 was ... overcome a key obstacle for many early stage organizations ... part of the sponsorship, Amgen launched two "Amgen Golden ...
(Date:6/22/2016)...  According to Kalorama Information, the dominant trends ... include significant efforts in automation as well as ... affordable sequencers, say the healthcare market research firm, ... sample prep materials.  The healthcare market research company,s ... Next Generation Sequencing (NGS) , highlights major trends ...
(Date:6/22/2016)... BELLINGHAM, Washington, USA (PRWEB) , ... June 21, 2016 , ... ... — and without cutting into the tissue — promise to enable both compact, wearable ... information and from even deeper under the skin. , Recent work and visionary future ...
Breaking Biology Technology: