Navigation Links

HOME >> BIOLOGY >> DEFINITION |

Ewens's sampling formula

In population genetics, **Ewens's sampling formula**, introduced by Warren Ewens , states that under certain conditions (specified below), if a random sample of *n* gametes is taken from a population and classified according to the gene at a particular locus then the probability that there are *a*_{1} alleles represented once in the sample, and *a*_{2} alleles represented twice, and so on, is

for some positive number θ, whenever *a*_{1}, ..., *a*_{n} is a sequence of nonnegative integers such that

The phrase "under certain conditions", used above, must of course be made precise. The assumptions are (1) the sample size *n* is small by comparison to the size of the whole population, and (2) the population is in statistical equilibrium under mutation and genetic drift and the role of selection at the locus in question is negligible, and (3) every mutant allele is novel.

This is a probability distribution on the set of all partitions of the integer *n*. Among probabilists and statisticians it is often called the **Ewens distribution**.

When θ = 0, the probability is 1 that all *n* genes are the same. When θ = 1, then the distribution is precisely that of the integer partition induced by a uniformly distributed random permutation. As the probability that no two of the *n* genes are the same approaches 1.

This family of probability distributions enjoys the property that if after the sample of *n* is taken, *m* of the *n* gametes are chosen without replacement, then the resulting probability distribution on the set of all partitions of the smaller integer *m* is just what the formula above would give if *m* were put in place of *n*.

- Warren Ewens, "The sampling theory of selectively neutral alleles",
*Theoretical Population Biology*, volume 3, pages 87—112, 1972. - J.F.C. Kingman, "Random partitions in population genetics",
*Proceedings of the Royal Society of London, Series A, Mathematical and Physical Sciences*, volume 361, number 1704, 1978.

'"/>

(Date:6/25/2020)... ... June 24, 2020 , ... ... and software-driven clinical data services that accelerate drug development, is collaborating with Karyopharm ... XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the first study ...

(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for ... use of mass spectrometry in this field has gained a lot of momentum in ... which approach to use (LBA or MS)?” In many cases, either technology can ...

(Date:6/19/2020)... ... ... The director of stem cell biotechnology company Asymmetrex , Dr. James L. Sherley, ... easier access to stem cell counting, they will soon make it a routine part ... in the U.S., Asymmetrex is offering free tissue stem cell counting at its ...

Breaking Biology News(10 mins):