Navigation Links
Chemiosmotic hypothesis


The Chemiosmotic Hypothesis is the proposal in 1961, by Peter D. Mitchell, that the mitochondrion functioned as a kind of electrochemical capacitor, using the energy of NADH and FADH2 to create a proton gradient across the mitochondrial membrane and that this energy was used by a reversible proton pump, the ATP synthase, to create ATP. This was a radical proposal at the time, and not well accepted. The prevailing view was that the energy of electron transfer was stored as a stable high potential intermediate, a chemically more conservative concept.

The problem with the older paradigm is that no high energy intermediate was ever found, and the evidence for proton pumping by the complexes of the electron transfer chain grew too great to be ignored. Eventually the weight of evidence began to favor the chemiosmotic hypothesis, and in 1978, Peter Mitchell was awarded the Nobel Prize in Chemistry.

see also: mitochondrion, chloroplasts, chemiosmotic potential, electron transfer chain, cytochrome

References:

http://www.life.uiuc.edu/crofts/bioph354/mitchell.html

http://www.owlnet.rice.edu/~bios301/Bios301/lecture/Lec11-Chemios-photo.pdf


'"/>


(Date:5/21/2020)... ... 2020 , ... Law Enforcement has always been a highly stressful career – ... of these men and women put them constantly in harm’s way both from the ... have always had to face very high daily stress. Now, COVID-19 introduces another even ...
(Date:5/14/2020)... ... May 12, 2020 , ... ... accurately and easily project contracted liabilities with payers, providers and pharmacies – ... discounts/rebates to Commercial and Government entities, Copay and Patient Assistance Program liabilities ...
(Date:5/11/2020)... ... May 11, 2020 , ... ... software platform for patients with implanted cardiac devices. The Octagos software allows healthcare ... portal. The software greatly simplifies the management of remote transmissions and at the ...
Breaking Biology News(10 mins):
Other biology definition