Navigation Links
Active site


The active site of an enzyme is the binding site where catalysis occurs. The structure and chemical properties of the active site allow the recognition and binding of the substrate.

The active site in many enzymes can be inhibited or suppressed by the presence of another molecule. There are three primary modes of inhibition. In competitive inhibition, the active site itself is blocked when a molecule chemically similar to the substrate binds to the active site but cannot be processed by the enzyme. In noncompetitive inhibition , the inhibitor binds to the enzyme at another site, the allosteric site, and this causes a structural change in the enzyme such that the active site is rendered useless. Uncompetitive inhibition , is similar to noncompetitive inhibition except that the inhibitor can only bind the enzyme-substrate complex rather than the free enzyme.

Models

There are several models of how enzymes work. The lock and key model and the induced fit model whereby the active site binds and encloses the substrate molecule. Often enzymes bond to their substrate by Van der Waals forces or hydrogen bonds between the R' groups in the amino acid monomers.


'"/>


(Date:7/30/2014)... cells types. Researchers would like to understand how to channel ... make up the organs and other structures of living organisms. ... sugars that dangle from proteins on surfaces of cells. , ... has created synthetic molecules that can stand in for the ... the process, they report in the Journal of the ...
(Date:7/30/2014)... the first high-resolution map of the carbon stocks ... Per. The new and improved methodology used to ... future market-based carbon economies. The new carbon ... and it provides the critical input to studies ... use, and enforcement purposes. The technique includes the ...
(Date:7/29/2014)... USA The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics. , ... BRAIN Initiative in the United States, and a special ... and provide examples of the impact that optics and ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3
... Memorial Sloan-Kettering Cancer Center have discovered that a new class ... work best in patients with mutations in the BRAF gene. ... the growth and survival of cancer cells and is mutated ... minority of patients with colon, breast, and lung cancers. The ...
... For the first time, ultrasound is being used in animal ... at the University of Pennsylvania School of Medicine completed a ... see a tumor's blood perfusion and then to treat it ... of treatment at an intensity similar to what is used ...
... week in Current Biology, tsunami damage to coral reefs ... was occasionally spectacular, but surprisingly limited, particularly when compared ... , Less than 100 days after the tsunami ... James Cook University, the Wildlife Conservation Society-Indonesia Program, and ...
Cached Biology News:Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs 2Penn researchers study the use of ultrasound for treatment of cancer 2
Other biology definitionOther Tags