Navigation Links
Active site


The active site of an enzyme is the binding site where catalysis occurs. The structure and chemical properties of the active site allow the recognition and binding of the substrate.

The active site in many enzymes can be inhibited or suppressed by the presence of another molecule. There are three primary modes of inhibition. In competitive inhibition, the active site itself is blocked when a molecule chemically similar to the substrate binds to the active site but cannot be processed by the enzyme. In noncompetitive inhibition , the inhibitor binds to the enzyme at another site, the allosteric site, and this causes a structural change in the enzyme such that the active site is rendered useless. Uncompetitive inhibition , is similar to noncompetitive inhibition except that the inhibitor can only bind the enzyme-substrate complex rather than the free enzyme.

Models

There are several models of how enzymes work. The lock and key model and the induced fit model whereby the active site binds and encloses the substrate molecule. Often enzymes bond to their substrate by Van der Waals forces or hydrogen bonds between the R' groups in the amino acid monomers.


'"/>


(Date:8/19/2014)... the world, leprosy and tuberculosis live side-by-side. Worldwide ... per year, with nearly all of them occurring ... vaccine Bacille Calmette-Guerin, or BCG, provides only partial ... more potent vaccine is needed to combat both ... weapon against both diseases., In a study published ...
(Date:8/19/2014)... devised a new implantable tissue scaffold coated with bone ... weeks. When applied to bone injuries or defects, this ... bone that looks and behaves just like the original ... a dramatic improvement over the current standard for treating ... of the patient,s body a painful process that ...
(Date:8/19/2014)... infants born with neonatal abstinence syndrome (NAS) secondary ... time going through withdrawal than others, but the ... and epigenetic (when genes are turned on or ... factors, researchers at Boston University School of Medicine ... first of its kind study to identify some ...
Breaking Biology News(10 mins):New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2Engineering new bone growth 2Engineering new bone growth 3In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2
... biofouling affects harbors around the world. It,s the ... on the bottom of boats and other surfaces. ... Kewalo Marine Laboratory have discovered a biological trigger behind ... life as miniscule larvae floating in the open ocean, ...
... Orleans, LA A team of scientists at LSU Health ... active form of E6-associated protein (E6AP), an enzyme that acts ... the first time, that the active form of E6AP is ... diverse as the ability of nerve cells to "rewire" themselves ...
... Fla. (Jan. 9, 2014) The current special issue ... National Academy of Inventors is devoted to ... Academy of Inventors (NAI) hosted by the University of ... attracted 200 inventors and innovators from 60 universities, research ...
Cached Biology News:Marine tubeworms need nudge to transition from larvae state 2LSUHSC research reveals structure of master regulator and new drug target for autism, cervical cancer 2National Academy of Inventors 2013 Conference showcased global innovation 2National Academy of Inventors 2013 Conference showcased global innovation 3National Academy of Inventors 2013 Conference showcased global innovation 4
Other biology definitionOther Tags