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'Chaperone' compounds offer new approach to Alzheimer's treatment

4/20/2014
NEW YORK, NY (April 20, 2014) A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell wher... [Comments]

Bulletproof nuclei? Stem cells exhibit unusual absorption property

4/20/2014
Stem cells the body's master cells demonstrate a bizarre property never before seen at a cellular level, according to a study published today from scientists at the University of Cambridge. The property known as auxeticity is one which may have application as wide-ranging as soundproofing, super-absorbent sponges and bulletproof vests. Most materials when stretched will contract. For exa... [Comments]

Computational method dramatically speeds up estimates of gene expression

4/20/2014
PITTSBURGHWith gene expression analysis growing in importance for both basic researchers and medical practitioners, researchers at Carnegie Mellon University and the University of Maryland have developed a new computational method that dramatically speeds up estimates of gene activity from RNA sequencing (RNA-seq) data. With the new method, dubbed Sailfish after the famously speedy fish, es... [Comments]

Cancer stem cells linked to drug resistance

4/20/2014
Most drugs used to treat lung, breast and pancreatic cancers also promote drug-resistance and ultimately spur tumor growth. Researchers at the University of California, San Diego School of Medicine have discovered a molecule, or biomarker, called CD61 on the surface of drug-resistant tumors that appears responsible for inducing tumor metastasis by enhancing the stem cell-like properties of can... [Comments]

Study of gut microbes, antibiotics: Clues to improving immunity in premature infants

4/20/2014
Mothers give a newborn baby a gift of germsgerms that help to kick-start the infant's immune system. But antibiotics, used to fend off infection, may paradoxically interrupt a newborn's own immune responses, leaving already-vulnerable premature babies more susceptible to dangerous pathogens. A new animal study by neonatology researchers at The Children's Hospital of Philadelphia (CHOP) sh... [Comments]

Dana-Farber researchers uncover link between Down syndrome and leukemia

4/20/2014
BOSTON Although doctors have long known that people with Down syndrome have a heightened risk of developing acute lymphoblastic leukemia (ALL) during childhood, they haven't been able to explain why. Now, a team of Dana-Farber Cancer Institute investigators has uncovered a connection between the two conditions. In a study posted online today by the journal Nature Genetics , the researche... [Comments]

Study casts doubt on climate benefit of biofuels from corn residue

4/20/2014
Lincoln, Neb., April 20, 2014 -- Using corn crop residue to make ethanol and other biofuels reduces soil carbon and can generate more greenhouse gases than gasoline, according to a study published today in the journal Nature Climate Change . The findings by a University of Nebraska-Lincoln team of researchers cast doubt on whether corn residue can be used to meet federal mandates to ramp u... [Comments]

Counterfeit contraceptives found in South America

4/18/2014
A survey of emergency contraceptive pills in Peru found that 28 percent of the batches studied were either of substandard quality or falsified. Many pills released the active ingredient too slowly. Others had the wrong active ingredient. One batch had no active ingredient at all. To detect the fake drugs, researchers at the Georgia Institute of Technology developed a sophisticated approac... [Comments]

MRI, on a molecular scale

4/18/2014
For decades, scientists have used techniques like X-ray crystallography and nuclear magnetic resonance imaging (NMR) to gain invaluable insight into the atomic structure of molecules, but such efforts have long been hampered by the fact that they demand large quantities of a specific molecule and often in ordered and crystalized form to be effective making it all but impossible to peer into t... [Comments]

Stanford researchers rethink 'natural' habitat for wildlife

4/18/2014
Protecting wildlife while feeding a world population predicted to reach 9 billion by 2050 will require a holistic approach to conservation that considers human-altered landscapes such as farmland, according to Stanford researchers. Wildlife and the natural habitat that supports it might be an increasingly scarce commodity in a world where at least three-quarters of the land surface is dire... [Comments]

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